K. Kleigrewe

Sex-specific fear acquisition following early life stress is linked to amygdala glutamate metabolism

This study examines sex-specific effects of early life stress on fear memory and amygdala metabolism, revealing sex-dependent changes in glutamate and metabolic pathways.

Diurnal rhythmicity of fecal microbiota and metabolite profiles in the first year of life: a randomized controlled interventional trial with infant formula

This study shows that microbiota and metabolite rhythmicity develops early in life, influenced by diet and breastfeeding, with GOS-supplemented formula promoting bifidobacteria.

Untargeted metabolomics reveals PTI-associated metabolites in cultivated tomato

The paper uses untargeted metabolomics to identify PTI-associated metabolites in tomato plants responding to fungal elicitors and pathogens.

Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer

The paper shows that secondary bile acids from gut bacteria worsen colorectal cancer in a Western diet model.

Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation

This study shows that altering meal timing (restricted feeding) can restore intestinal clock function and reduce inflammation in IBD models.

Nutritional and host environments determine community ecology and keystone species in a synthetic gut bacterial community

The paper identifies keystone species in a synthetic gut bacterial community and shows their roles vary with nutritional and host environments.

Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice

The paper shows that phages targeting protective gut bacteria increase susceptibility to Salmonella Typhimurium infection in gnotobiotic mice.

Genetic and environmental circadian disruption induce metabolic impairment through changes in the gut microbiome

This study shows that circadian disruption from genetic and environmental factors causes metabolic issues by altering gut microbiome function and rhythmicity.

The intestinal circadian clock drives microbial rhythmicity to maintain gastrointestinal homeostasis

This study shows that the host's intestinal circadian clock regulates microbial rhythms, maintaining gut homeostasis through metabolite production and immune system modulation.

Exploring the interaction network of a synthetic gut bacterial community

This study investigates the interaction network of a synthetic gut bacterial community, revealing exploitative and interference competition shaping community dynamics.