Facilitation by a hERG blocker is induced by pore opening and operates by pore reopening
K. Furutani, R. Kawano, M. Ichiwara, R. Adachi, C. E. Clancy, J. T. Sack, S. Kita
This study investigates how nifekalant, a hERG blocker, facilitates hERG channel activation through pore opening rather than voltage sensors.
bioRxiv · May 26, 2022 · PreprintPharmacology & Toxicology