Author

K. G. Abdullah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

L. C. Gattie· 3 shared T. E. Richardson· 3 shared D. D. Shi· 2 shared L. G. Zacharias· 2 shared M. R. Savani· 2 shared M. S. Martin-Sandoval· 2 shared R. J. DeBerardinis· 2 shared S. K. McBrayer· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

L. C. Gattie

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Matched three-dimensional organoids and two-dimensional cell lines of melanoma brain metastases mirror response to targeted molecular therapy

W. H. Hicks, L. C. Gattie, J. I. Traylor, D. Davar, Y. G. Najjar, T. E. Richardson, S. K. McBrayer, K. G. Abdullah

This study develops matched patient-derived organoids and cell lines from melanoma brain metastases to evaluate responses to targeted therapies, finding both models respond to BRAF and MEK inhibitors.

bioRxiv · Jan 18, 2024Cancer Biology

Stable isotope tracing in human plasma-like medium reveals metabolic and immune modulation of the glioblastoma microenvironment

M. R. Savani, M. El Shami, L. C. Gattie, B. C. Smith, W. H. Hicks, S. S. Oken, L. G. Zacharias, M. S. Martin-Sandoval, E. Y. Montgomery, Y. Xiao, D. D. Shi, J. N. Rich, T. E. Richardson, P. O. Zinn, B. C. Lega, , K. G. Abdullah

This paper develops an in vitro method using human plasma-like medium to study glioma metabolism and immune interactions, revealing microenvironment-dependent metabolic features and immune responses.

bioRxiv · May 29, 2023Cancer Biology

De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

D. D. Shi, M. R. Savani, M. M. Levitt, A. C. Wang, J. E. Endress, C. E. Bird, J. Buehler, S. A. Stopka, M. S. Regan, Y.-F. Lin, W. Gao, J. Khanal, M. Xu, B. Huang, R. B. Jennings, , McBray

This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.

bioRxiv · Nov 30, 2021Cancer Biology