E. Sahai

Deciphering the diversity and sequence of extracellular matrix and cellular spatial patterns in lung adenocarcinoma using topological data analysis

This study uses topological data analysis to quantify ECM architecture and spatial patterns in lung adenocarcinoma, revealing progressive changes linked to immune exclusion and metabolic shifts.

Cancer cell - fibroblast crosstalk via HB-EGF/EGFR/MEK signalling promotes macrophage recruitment in squamous cell carcinoma

The paper identifies a gene expression signature of cancer-fibroblast crosstalk in squamous cell carcinoma and shows its prognostic relevance and role in macrophage recruitment.

Multi-site assessment of reproducibility in high-content live cell imaging data

This study assesses reproducibility in high-content live cell imaging data across multiple sites and identifies sources of variability, showing that batch correction improves meta-analysis of perturbation experiments.

Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma

This study identifies factors determining collective invasion patterns in squamous cell carcinoma, showing that high cell-cell adhesion and proteolysis promote aggressive growth and invasion.

EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

This study identifies EphB6 as a regulator of the TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells in a foreign environment.

Dissecting targeted therapy resistance: Integrating models to quantify environment mediated drug resistance

This paper quantifies environmental contributions to drug resistance in melanoma, revealing heterogeneity that impacts treatment dynamics and suggests strategies to target both tumor and stroma.