Transgenic Mouse Models Establish a Protective Role of Type 1 IFN Response in SARS-CoV-2 infection-related Immunopathology
N. R. Chauhan, S. Kundu, R. Bal, D. Chattopadhyay, S. Mehto, R. Sahu, R. Yadav, S. Krishna, K. K. Jena, S. Satapathy, K. C. Murmu, B. Singh, S. K. Das, S. Jena, K. H. Harshan, , S. Chauhan
This study uses transgenic mouse models to show that a heightened type 1 IFN response protects against SARS-CoV-2-induced immunopathology, with Irgm1 as a potential therapeutic target.
bioRxiv · Dec 17, 2022 · PreprintImmunology