K. Kovalev

CryoRhodopsins: a comprehensive characterization of a group of microbial rhodopsins from cold environments

The paper characterizes CryoRhodopsins from cold environments, revealing their dual functionality and structural adaptations to low temperatures.

A novel subgroup of light-driven sodium pumps with an additional Schiff base counterion

The paper identifies a new subgroup of light-driven sodium pumps with an additional glutamic acid residue that reduces pH sensitivity for sodium transport.

Flotillin-Associated rhodopsin (FArhodopsin), a widespread paralog of proteorhodopsin in aquatic bacteria with streamlined genomes

The paper identifies a new class of rhodopsins, FArhodopsins, found in marine and freshwater microbes, associated with membrane microdomains and potentially retinal-less function.

Structural insights into 3Fe-4S ferredoxins diversity in M.tuberculosis highlighted by a first redox complex with P450.

The paper solves the structures of 3Fe-4S ferredoxins from M. tuberculosis and their complex with CYP143, revealing structural and functional insights into redox interactions.

Structural basis for receptor selectivity and inverse agonism in S1P5 receptors

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

Insights into the mechanisms of LOV domain color tuning from a set of high-resolution X-ray structures

The paper investigates how mutations of Gln148 in LOV domains affect their absorption spectra and structure, revealing blue shifts and pH sensitivity in certain variants.

Structural and mechanistic insight into spectral tuning in flavin-binding fluorescent proteins

The paper identifies structural and mechanistic causes of spectral tuning in flavin-binding fluorescent proteins through mutagenesis, X-ray crystallography, and computational methods, enabling two-color microscopy.

Metabolic fate of human immunoactive sterols in Mycobacterium tuberculosis

The paper identifies Mtb enzymes that metabolize human immune oxysterols and vitamin D3 derivatives, revealing a potential drug target for tuberculosis treatment.

Viral channelrhodopsins: calcium-dependent Na+/K+ selective light-gated channels

The paper characterizes two viral channelrhodopsins, showing they are Ca2+-dependent Na+/K+ channels with unique optogenetic properties and structural differences from known channelrhodopsins.

Molecular mechanism of light-driven sodium pumping

The paper elucidates the molecular mechanism of Na+ pumping by KR2 rhodopsin using crystal structures and molecular dynamics, revealing a switching mechanism and structural similarities to channelrhodopsins.

High Resolution Structural Insights into Heliorhodopsin Family

The paper presents high-resolution structures of two HeR-48C12 states, revealing unique features and suggesting potential enzymatic activity and involvement in redox processes.