K. L. Jones

The Effects of Nitric Oxide on Choroidal Gene Expression

This study investigates how nitric oxide affects choroidal gene expression in chick eyes, identifying 837 differentially expressed genes and associated biological pathways.

Single Cell Transcriptomics Identifies Distinct Choroid Cell Populations Involved in Visually Guided Eye Growth

The paper uses scRNA-seq to identify choroid cell populations involved in emmetropization, finding a rare neuronal-like cell population with light-sensitive gene expression.

A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

This paper identifies a druggable metabolic vulnerability in diffuse midline glioma through a CRISPR screen, showing that inhibition of DHODH reduces pyrimidine biosynthesis and extends survival in mouse models.

Ghrelin proteolysis by insulin-degrading enzyme

The paper investigates ghrelin proteolysis by insulin-degrading enzyme, identifying cleavage sites and developing a fluorogenic substrate for future studies.

Redefining De Novo Gammaherpesvirus Infection Through High-Dimensional, Single-Cell Analysis of Virus and Host

This paper uses single-cell RNA sequencing and mass cytometry to analyze variation in viral and host gene expression during de novo gammaherpesvirus infection.

Cross-kingdom signalling regulates spore germination in the moss Physcomitrella patens

This study shows that AHLs affect spore germination in the moss Physcomitrella patens and that sporophytes are associated with AHL-producing bacteria.

Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targets

This study characterizes treatment-induced high-grade gliomas (TIHGGs) through molecular profiling, identifying distinct subgroups and potential therapeutic targets.