Author

K. Lawrenson

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Biology Disciplines

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Cancer Biology· 7 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 5 Research Focus:differential expression· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Assay:ChIP-seq· 2

Frequent Co-Authors

R. I. Corona· 5 shared J. Reddy· 4 shared M. L. Freedman· 4 shared X. Lin· 4 shared J.-H. Seo· 3 shared R. Drapkin· 3 shared R. Nameki· 3 shared S. A. Gayther· 3 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersCancer Biology

R. I. Corona

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8 papers

Recent·Most cited

MYBL2 drives prostate cancer plasticity and identifies CDK2 as a therapeutic vulnerability in RB1-loss and neuroendocrine prostate cancer

L. Ellis, B. German, J. N. Singh, D. L. Burkhart, A. Sheahan, H. Bergom, K. L. Morel, H. Beltran, J. Hwang, K. Lawrenson

This study identifies MYBL2 as a master regulator of phenotypic plasticity in prostate cancer and shows CDK2 inhibition as a potential therapeutic strategy for MYBL2-driven tumors.

bioRxiv · Jan 31, 2024 · PreprintCancer Biology

Human fallopian tube single-cell analysis reveals monocytic transcriptional and interaction changes in high-grade serous ovarian cancers

J. Brand, M. Haro, X. Lin, S. M. McGregor, K. Lawrenson, H. Q. Dinh

The paper analyzes human fallopian tube single-cell RNA-seq data to show increased monocyte abundance and altered immune interactions in high-grade serous ovarian cancers.

bioRxiv · Jul 14, 2023 · PreprintCancer Biology

Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development

R. Nameki, H. Chang, P. H. Yu, F. Abbasi, X. Lin, J. Reddy, M. Haro, M. Fonseca, M. L. Freedman, R. Drapkin, R. Corona, K. Lawrenson

This study identifies MECOM, PAX8, SOX17, and WT1 as master regulators in HGSC, showing their rewired cistromes and tumor-specific inhibition potential.

bioRxiv · Apr 11, 2023 · PreprintCancer Biology

Rare germline genetic variation in PAX8 transcription factor binding sites and susceptibility to epithelial ovarian cancer

S. A. M. Ezquina, M. Jones, E. Dicks, A. de Vries, P.-C. Peng, R. I. Corona, K. Lawrenson, J. P. Tyrer, D. Hazelett, J. D. Brenton, A. C. Antoniou, S. A. Gayther, P. D. P. Pharoah

This study investigates rare germline variation in PAX8 binding sites for ovarian cancer risk using burden testing but finds no significant association.

medRxiv · Mar 22, 2023 · PreprintGenetic & Genomic Medicine

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

S. C. Baca, D. Y. Takeda, J.-H. Seo, J. Hwang, S. Y. Ku, R. Arafeh, T. Arnoff, S. Agarwal, C. Bell, E. O'Connor, X. Qiu, S. Abu Alaiwi, R. I. Corona, M. A. S. Fonseca, C. Giambartolomei, , M. L. Freedman

The paper identifies FOXA1 reprogramming in NEPC and shows its role in maintaining NE lineage features through epigenomic profiling.

bioRxiv · Oct 23, 2020Cancer Biology

PAX8 orchestrates an angiogenic program through interaction with SOX17

D. Chaves-Moreira, M. A. Mitchell, C. Arruza, P. Rawat, S. Sidoli, R. Nameki, J. Reddy, R. I. Corona, S. Ma, B. Winterhoff, G. E. Konecny, B. A. Garcia, D. C. Brady, K. Lawrenson, P. J. Morin, R. Drapkin

This study identifies SOX17 as a PAX8-interacting partner and shows their role in regulating tumor angiogenesis in ovarian cancer, suggesting a new therapeutic target.

bioRxiv · Sep 9, 2020 · PreprintCancer Biology

Predicting master transcription factors from pan-cancer expression data

J. Reddy, M. A. S. Fonseca, R. I. Corona, R. Nameki, F. Segato Dezem, I. A. Klein, H. Chang, D. Chaves-Moreira, L. Afeyan, T. M. Malta, X. Lin, F. Abbasi, A. Font-Tello, T. Sabedot, P. Cejas, , K. Lawrenson

This paper introduces CaCTS, an algorithm that identifies candidate master transcription factors (MTFs) across 34 cancer types using RNA-seq data, revealing novel MTFs and functional groupings.

bioRxiv · Nov 12, 2019Cancer Biology

Non-coding Somatic Mutations Converge on the PAX8 Pathway in Epithelial Ovarian Cancer

R. I. Corona, J.-H. Seo, X. Lin, D. J. Hazelett, J. Reddy, F. Abassi, Y. G. Lin, P. Y. Mhawech-Fauceglia, J. Lester, S. P. Shah, D. G. Huntsman, A. Gusev, B. Y. Karlan, B. P. Berman, M. L. Freedman, , K. Lawrenson

The paper identifies histotype-specific regulatory elements in ovarian cancer by integrating chromatin landscapes and somatic mutations, highlighting the PAX8 pathway's role in tumor development.

bioRxiv · Feb 1, 2019Cancer Biology