F. Abbasi

Lac-Phe mediates the anti-obesity effect of metformin

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

CFM: Confinement Force Microscopy-a dynamic, precise and stable microconfiner for traction force microscopy in spatial confinement

This paper introduces CFM, a method to dynamically control and measure traction forces in confined environments, revealing two phases of cellular response to confinement.

Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development

This study identifies MECOM, PAX8, SOX17, and WT1 as master regulators in HGSC, showing their rewired cistromes and tumor-specific inhibition potential.

X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

This study identifies X chromosome dosage and DHA reduction as drivers of statin-induced dysglycemia and mitochondrial dysfunction in females.

Pressure drives rapid burst-like collective migration from 3D cancer aggregates

The paper demonstrates that pressure differences inside 3D cancer aggregates drive rapid burst-like collective migration in HeLa cells, independent of ECM pulling forces.

Predicting master transcription factors from pan-cancer expression data

This paper introduces CaCTS, an algorithm that identifies candidate master transcription factors (MTFs) across 34 cancer types using RNA-seq data, revealing novel MTFs and functional groupings.