Author

K. M. Dave

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

D. S. Manickam· 3 shared Y. S. Kamte· 3 shared J. Milosevic· 2 shared P. Khare· 2 shared S. Shiva· 2 shared S.-y. Zheng· 2 shared A. Burch· 1 shared A. D'Souza· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBioengineering

D. S. Manickam

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Author profile →

4 papers

Recent·Most cited

Mitochondria-containing extracellular vesicles from mouse vs. human brain endothelial cells for ischemic stroke therapy

K. M. Dave, V. R. Venna, K. S. Rao, D. B. Stolz, B. Brady, V. A. Quaicoe, M. Maniskas, E. E. Hildebrand, D. Green, M. Chen, J. Milosevic, S.-y. Zheng, S. Shiva, L. D. McCullough, D. S. Manickam

This study compares the therapeutic efficacy of mitochondria-containing extracellular vesicles from mouse and human brain endothelial cells in a mouse stroke model, finding that mouse-derived vesicles are more effective.

bioRxiv · Jan 16, 2024 · PreprintBioengineering

Effect of homotypic vs. heterotypic interactions on the cellular uptake of extracellular vesicles

J. R. Jhaveri, P. Khare, P. P. Pinky, Y. S. Kamte, M. N. Chandwani, J. Milosevic, N. Abraham, K. M. Dave, S.-y. Zheng, L. O'Donnell, D. S. Manickam

This study compares homotypic and heterotypic EV interactions on uptake in BECs and macrophages, finding membrane fusion dominates uptake in low-pinocytic cells.

bioRxiv · Oct 23, 2023 · PreprintBioengineering

Development of lipidoid nanoparticles for siRNA delivery to neural cells

P. Khare, K. M. Dave, Y. S. Kamte, M. A. Manoharan, L. A. O'Donnell, D. S. Manickam

This study demonstrates that lipidoid nanoparticles can efficiently and safely deliver siRNA to neural cells, outperforming a commercial transfection agent in terms of safety.

bioRxiv · Jul 28, 2021Bioengineering

Microvesicles Transfer Mitochondria and Increase Mitochondrial Function in Brain Endothelial Cells

A. D'Souza, A. Burch, K. M. Dave, A. Sreeram, M. S. Reynolds, D. X. Dobbins, Y. S. Kamte, W. Zhao, C. Sabatelle, G. M. Joy, V. Soman, U. R. Chandran, S. Shiva, N. Quillinan, P. S. Herson, D. S Manickam

This paper shows that microvesicles transfer mitochondria to brain endothelial cells and neurons, increasing ATP levels under ischemic conditions, while exosomes do not affect mitochondrial function.

bioRxiv · Apr 10, 2021Bioengineering