Author

J. Milosevic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2

Frequent Co-Authors

D. B. Sykes· 2 shared D. S. Manickam· 2 shared J. I. Johnsen· 2 shared K. M. Dave· 2 shared N. Baryawno· 2 shared P. Kogner· 2 shared S.-y. Zheng· 2 shared T. K. Olsen· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

D. B. Sykes

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mitochondria-containing extracellular vesicles from mouse vs. human brain endothelial cells for ischemic stroke therapy

K. M. Dave, V. R. Venna, K. S. Rao, D. B. Stolz, B. Brady, V. A. Quaicoe, M. Maniskas, E. E. Hildebrand, D. Green, M. Chen, J. Milosevic, S.-y. Zheng, S. Shiva, L. D. McCullough, D. S. Manickam

This study compares the therapeutic efficacy of mitochondria-containing extracellular vesicles from mouse and human brain endothelial cells in a mouse stroke model, finding that mouse-derived vesicles are more effective.

bioRxiv · Jan 16, 2024 · PreprintBioengineering

Effect of homotypic vs. heterotypic interactions on the cellular uptake of extracellular vesicles

J. R. Jhaveri, P. Khare, P. P. Pinky, Y. S. Kamte, M. N. Chandwani, J. Milosevic, N. Abraham, K. M. Dave, S.-y. Zheng, L. O'Donnell, D. S. Manickam

This study compares homotypic and heterotypic EV interactions on uptake in BECs and macrophages, finding membrane fusion dominates uptake in low-pinocytic cells.

bioRxiv · Oct 23, 2023 · PreprintBioengineering

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

B. T. Do, P. P. Hsu, S. Y. Vermeulen, Z. Wang, T. Hirz, K. L. Abbott, N. Aziz, J. M. Replogle, S. Bjelosevic, J. Paolino, S. Nelson, S. Block, A. M. Darnell, R. Ferreira, H. Zhang, , M. G. Vander Heiden

The paper shows that nucleotide depletion and DNA replication stress drive cell fate transitions in hematopoietic systems by activating lineage-specific maturation genes.

bioRxiv · Aug 16, 2022Cancer Biology

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma

T. K. Olsen, C. Dyberg, B. Embaie, A. Alchahin, J. Milosevic, J. Otte, C. Tummler, I. H. Myrberg, E. M. Westerhout, J. Koster, R. Versteeg, P. Kogner, J. I. Johnsen, D. B. Sykes, N. Baryawno

This study identifies DHODH as a prognostic marker and therapeutic target in neuroblastoma, showing its inhibition improves survival in preclinical models and suggests combination therapy with temozolomide.

bioRxiv · Sep 25, 2021Cancer Biology

PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors.

J. Milosevic, S. Fransson, M. Gulyas, G. Gallo-Oller, T. K. Olsen, D. Treis, M. Wickstrom, L. H. Elfman, B. Sveinbjornsson, F. Hertwig, C. Bartenhagen, S. Reinsbach, M. Wilhelm, F. Abel, N. Javanmardi, , P. Kogner

This study identifies PPM1D as an oncogene and therapeutic target in neuroblastoma by showing its role in p53 inactivation and tumor growth.

bioRxiv · Sep 4, 2020 · PreprintCancer Biology