Author

U. R. Chandran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Amalric· 1 shared A. Burch· 1 shared A. Chang· 1 shared A. D'Souza· 1 shared A. Kulkarni· 1 shared A. L. Szymczak-Workman· 1 shared A. R. Cole· 1 shared A. Sreeram· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Amalric

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression

N. K. Tangudu, R. Buj, H. Wang, J. Wang, A. R. Cole, A. Uboveja, R. Fang, A. Amalric, P. Sajjakulnukit, M. A. Lyons, K. Cooper, N. W. Hempel, N. W. Snyder, C. A. Lyssiotis, U. R. Chandran, K. M. Aird

This study identifies de novo purine metabolism as a vulnerability in cancers with low p16 expression, showing sensitivity to anti-folate drugs like methotrexate.

bioRxiv · Jul 15, 2023Cancer Biology

Microvesicles Transfer Mitochondria and Increase Mitochondrial Function in Brain Endothelial Cells

A. D'Souza, A. Burch, K. M. Dave, A. Sreeram, M. S. Reynolds, D. X. Dobbins, Y. S. Kamte, W. Zhao, C. Sabatelle, G. M. Joy, V. Soman, U. R. Chandran, S. Shiva, N. Quillinan, P. S. Herson, D. S Manickam

This paper shows that microvesicles transfer mitochondria to brain endothelial cells and neurons, increasing ATP levels under ischemic conditions, while exosomes do not affect mitochondrial function.

bioRxiv · Apr 10, 2021Bioengineering

Expression of Tim-3 drives naive Treg to an effector-like state with enhanced suppressive activity

H. Banerjee, H. Nieves-Rosado, A. Kulkarni, B. Murter, U. R. Chandran, A. Chang, A. L. Szymczak-Workman, L. Vujanovic, R. L. Ferris, L. P. Kane

The paper shows that Tim-3 expression in Treg cells drives them to an effector-like state with enhanced suppressive activity, promoting tumor growth.

bioRxiv · Jul 31, 2020 · PreprintImmunology