Author

D. J. Owens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 2

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. P. Sharples· 3 shared D. C. Turner· 3 shared R. A. Seaborne· 3 shared A. K. Larin· 2 shared C. E. Stewart· 2 shared D. C. Hughes· 2 shared D. V. Popov· 2 shared E. A. Semenova· 2 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

A. P. Sharples

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Lamin-related congenital muscular dystrophy alters mechanical signaling and skeletal muscle growth

D. J. Owens, J. Messeant, S. Moog, M. Viggars, A. Ferry, K. Mamchaoui, E. Lacene, N. Romero, A. Brull, G. Bonne, G. S. Butler-Bowne, C. Coirault

This study investigates how LMNA mutations affect skeletal muscle growth and mechanical signaling in muscle stem cells and mouse models, finding impaired differentiation and hypertrophy in LMNA-CMD.

bioRxiv · Aug 6, 2020Physiology

Knockdown of the E3 Ubiquitin ligase UBR5 and its role in skeletal muscle anabolism

D. C. Turner, D. C. Hughes, L. M. Baehr, R. A. Seaborne, M. Viggars, J. C. Jarvis, P. P. Gorski, C. E. Stewart, D. J. Owens, S. C. Bodine, A. P. Sharples

This study shows that knocking down UBR5 leads to skeletal muscle atrophy by disrupting anabolic signaling pathways.

bioRxiv · Jun 5, 2020Cell Biology

DNA methylation across the genome in aged human skeletal muscle tissue and stem cells: The role of HOX genes and physical activity

D. C. Turner, P. P. Gorski, M. F. Maasar, R. A. Seaborne, P. Baumert, A. D. Brown, M. O. Kitchen, R. M. Erskine, I. Dos-Remedios, S. Voisin, N. Eynon, R. I. Sultanov, O. V. Borisov, A. K. Larin, E. A. Semenova, , A. P. Sharples

This study identifies age-related hypermethylation in HOX genes in aged human skeletal muscle and stem cells, with physical activity inversely affecting methylation in some genes.

bioRxiv · Dec 27, 2019Physiology

UBR5 is a Novel E3 Ubiquitin Ligase involved in Skeletal Muscle Hypertrophy and Recovery from Atrophy

R. A. Seaborne, D. C. Hughes, D. C. Turner, D. J. Owens, L. M. Baehr, P. Gorski, E. A. Semenova, O. V. Borisov, A. K. Larin, D. V. Popov, E. V. Generozov, H. Sutherland, I. I. Ahmetov, J. C. Jarvis, S. C. Bodine, A. P. Sharples

This paper identifies UBR5 as a novel E3 ubiquitin ligase inversely regulated to MuRF1/MAFbx, epigenetically modulated during skeletal muscle recovery from atrophy and hypertrophy, and genetically associated with muscle fiber size and strength traits.

bioRxiv · Apr 29, 2019Physiology

MICRORNA-184 AND ITS LNCRNA SPONGE UCA1 ARE INDUCED IN WOUNDED KERATINOCYTES IN A STORE-OPERATED CALCIUM ENTRY-DEPENDENT MANNER

A. Richardson, D. J. Owens, K. Ross

This study shows that miR-184 and its sponge UCA1 are induced in wounded keratinocytes via SOCE, supporting migration and potentially regulating miR-184 activity.

bioRxiv · Jul 6, 2018Cell Biology