CDK1 dependent phosphorylation of hTERT contributes to cancer progression
M. Yasukawa, Y. Ando, T. Yamashita, Y. Matsuda, S. Shoji, M. S. Morioka, H. Kawaji, K. Shiozawa, T. Abe, S. Yamada, M. K. Kaneko, Y. Kato, Y. Furuta, T. Kondo, M. Shirouzu, , K. Masutomi
The paper shows CDK1 phosphorylates hTERT at threonine 249, which is required for RdRP activity and promotes cancer progression independently of telomerase.
bioRxiv · Feb 21, 2019Cancer Biology