Y. Furuta

A stress sensor IRE1α is required for bacterial exotoxin-induced inflammasome activation in tissue-resident macrophages

The paper shows that IRE1α is essential for CTB and CT-induced IL-1β production in tissue-resident macrophages via NLRP3 and pyrin inflammasomes.

Identification, expression, and purification of DNA cytosine 5-methyltransferases with short recognition sequences

The paper identifies and characterizes DNA cytosine 5-methyltransferases with short recognition sequences that do not overlap with CG dinucleotides, enabling fine epigenetic mapping.

Silkworm model for Bacillus anthracis infection and virulence determination

This study establishes a silkworm infection model for Bacillus anthracis to assess virulence and antibiotic efficacy, identifying attenuated mutants with reduced pathogenicity.

Calcium ions trigger the exposure of phosphatidylserine on the surface of necrotic cells

The paper identifies a Ca2+-dependent pathway that triggers phosphatidylserine exposure on necrotic neurons in C. elegans.

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

The paper shows CDK1 phosphorylates hTERT at threonine 249, which is required for RdRP activity and promotes cancer progression independently of telomerase.

Therapeutic effects of favipiravir against severe fever with thrombocytopenia syndrome virus infection in a lethal mouse model: dose-efficacy studies upon oral administration

This study shows that oral favipiravir at 120 or 200 mg/kg/day effectively treats SFTSV infection in IFNAR-/- mice when started within 4 days post-infection, preventing mortality.