S. Kaneko

Transcriptional landscape of the dorsal raphe serotonin neurons rendering stress resiliency

This study identifies gene expression changes in DRN serotonin neurons under antidepressant treatment and depression models, revealing S100a10 as a prodepressive gene and its regulatory pathway.

Fruitless mating with the exes: the irreversible parthenogenesis in a stick insect

This study examines sexual reproduction in the Japanese stick insect Ramulus mikado, finding that rare males lack sperm and offspring show no paternal alleles, supporting irreversible asexual reproduction.

Phylogeographical evidence for historical long-distance dispersal in the flightless stick insect Ramulus mikado

The paper investigates historical avian-mediated dispersal in Ramulus mikado stick insects using molecular data, finding low genetic differentiation and identical genotypes across distant populations.

Reactive blue 2 labels protamine in late-haploid spermatids and spermatozoa and can be used for toxicity evaluation

This study shows that Reactive Blue 2 (RB2) specifically stains protamine in late-haploid spermatids and spermatozoa, and can be used to evaluate male reproductive toxicity in mice.

Infection-Induced Extracellular Vesicles Evoke Neuronal Transcriptional and Epigenetic Changes

This study shows that Toxoplasma-induced neuronal extracellular vesicles reduce DBH expression and induce DNA methylation changes in host cells.

Distinct CD8+ T Cell Programming in the Tumor Microenvironment Contributes to Sex Bias in Bladder Cancer Outcome

The paper identifies sex differences in CD8+ T cell programming in bladder cancer, showing male-biased T cell exhaustion and implications for immune checkpoint therapy.

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

The paper shows CDK1 phosphorylates hTERT at threonine 249, which is required for RdRP activity and promotes cancer progression independently of telomerase.

Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin

This study shows that PRC2 activity is controlled by allosteric activation, independent of its chromatin recruitment, and identifies vulnerabilities in PRC2-addicted cancers.