Author

M. K. Kaneko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:electronic health records· 1

Frequent Co-Authors

Y. Kato· 4 shared K. Iwasaki· 2 shared M. Hirose· 2 shared R. Aruga· 2 shared R. Oi· 2 shared T. Miyake· 2 shared T. Nogi· 2 shared Y. Akiyama· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

Y. Kato

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies

T. Inoue, Y. Yamamoto, K. Sato, Y. Nakamura, Y. Shimizu, M. Ogawa, T. Onodera, Y. Takahashi, T. Wakita, M. K. Kaneko, M. Fukasawa, Y. Kato, K. Noguchi

This study develops bispecific antibodies that restore effectiveness against SARS-CoV-2 variants resistant to existing antibodies by combining non-neutralizing antibodies targeting different epitopes.

bioRxiv · Oct 26, 2023Microbiology

Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP

Y. Imaizumi, K. Takanuki, T. Miyake, M. Takemoto, K. Hirata, M. Hirose, R. Oi, T. Kobayashi, K. Miyoshi, R. Aruga, T. Yokoyama, S. Katagiri, H. Matsuura, K. Iwasaki, T. Kato, , T. Nogi

This study elucidates the mechanism of intramembrane proteolysis by E. coli RseP through crystal structures and mutational analysis, revealing a gating mechanism for substrate entry.

bioRxiv · Jan 31, 2022Biochemistry

Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope tag insertion

R. Tamura-Sakaguchi, R. Aruga, M. Hirose, T. Ekimoto, T. Miyake, Y. Hizukuri, R. Oi, M. K. Kaneko, Y. Kato, Y. Akiyama, M. Ikeguchi, K. Iwasaki, T. Nogi

The paper improves epitope tag insertion for 3D structure determination by using PA14 tags, which reduce structural changes in targets compared to PA12 tags.

bioRxiv · Oct 6, 2020Biophysics

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

M. Yasukawa, Y. Ando, T. Yamashita, Y. Matsuda, S. Shoji, M. S. Morioka, H. Kawaji, K. Shiozawa, T. Abe, S. Yamada, M. K. Kaneko, Y. Kato, Y. Furuta, T. Kondo, M. Shirouzu, , K. Masutomi

The paper shows CDK1 phosphorylates hTERT at threonine 249, which is required for RdRP activity and promotes cancer progression independently of telomerase.

bioRxiv · Feb 21, 2019Cancer Biology