Author

K. Mekhail

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. Astori· 1 shared A. Iqbal· 1 shared B. Raught· 1 shared C. N. Antonescu· 1 shared D. Y. Zhao· 1 shared E. Latreille· 1 shared G. D. Fairn· 1 shared J. F. Greenblatt· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. Astori

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Author profile →

2 papers

Recent·Most cited

Fatty Acid Synthase inhibitor TVB-3166 prevents S-acylation of the Spike protein of human coronaviruses.

K. Mekhail, M. Lee, M. Sugiyama, A. Astori, J. St-Germain, E. Latreille, N. Khosraviani, K. Wei, W. L. Lee, C. N. Antonescu, B. Raught, G. D. Fairn

This study shows that TVB-3166 inhibits S-acylation of coronavirus Spike proteins, reducing viral spread and improving survival in mice.

Journal of Lipid Research · Sep 1, 2022Peer-reviewedCell Biology

A small-molecule antagonist for the Tudor domain of SMN disrupts the interaction between SMN and RNAP II

Y. Liu, A. Iqbal, W. Li, Z. Ni, D. Y. Zhao, K. J. Abraham, W. Tempel, X. Guo, M. Zhou, P. J. Brown, S. Qin, K. Mekhail, J. F. Greenblatt, J. Min

This paper identifies a small-molecule antagonist targeting the Tudor domain of SMN, disrupting its interaction with RNAP II and mimicking SMN depletion effects.

bioRxiv · Mar 2, 2022 · PreprintBiochemistry