Z. Ni

Targeted inhibition of BET proteins in HPV-16 associated head and neck squamous cell carcinoma reveals heterogeneous transcription response

This study shows BET inhibition reduces E6 and E7 expression in HPV-16 HNSCC, with variable effects on p53 and Rb, and induces G1 arrest and apoptosis.

Pangenome-based dynamic trajectories of intracellular gene transfers in Poaceae unveil a high rate of unceasing integration and selective retention in Triticeae

This study maps the dynamic trajectories of intracellular gene transfers in Poaceae using a novel tool, revealing lineage-specific patterns and functional roles of nuclear organelle genes.

ATG5- and ATG7-mediated autophagy regulates pollen tube guidance and male fertility in Arabidopsis thaliana

Programmable acetylation modification of bacterial proteins by a Cas12a-guided acetyltransferase

This study develops a TPA system using Cas12a and bacterial acetylase At2 to enable in situ targeted protein acetylation in bacteria, demonstrating its specificity and efficiency for modification studies.

A small-molecule antagonist for the Tudor domain of SMN disrupts the interaction between SMN and RNAP II

This paper identifies a small-molecule antagonist targeting the Tudor domain of SMN, disrupting its interaction with RNAP II and mimicking SMN depletion effects.

Epilipidomics platform for holistic profiling of oxidized complex lipids in blood plasma of obese individuals

The paper develops an epilipidomics platform to profile oxidized complex lipids in blood plasma of obese individuals and identifies metabolic disorder-related lipid modification signatures.

Investigation on the changes of Bifidobacterium and lactic acid bacteria in soybean meal fermented feed

This study investigates how combining Bifidobacterium lactis with Bacillus coagulans or Lactobacillus paracasei enhances its growth during soybean meal fermentation under anaerobic conditions.

Multi-omics analysis for potential inflammation-related genes involved in tumor immune evasion via extended application of epigenetic data

The paper identifies STAT2 as a regulator of PD-L1 expression through multi-omics analysis and experimental validation, linking it to tumor immune evasion.

AdipoAtlas: A Reference Lipidome for Human White Adipose Tissue

The paper presents AdipoAtlas, a reference lipidome of human white adipose tissue, identifying lipid remodeling in lean and obese individuals.

The abaI/abaR quorum sensing system effects pathogenicity in Acinetobacter baumannii

This study investigates the role of the abaI/abaR quorum sensing system in Acinetobacter baumannii virulence, showing its impact on growth, biofilm formation, antimicrobial susceptibility, and gene expression.

The influence of positive emotion and negative emotion on false memory based on EEG signals analysis

This study examines how positive and negative emotions affect false memory using EEG, finding higher false memory rates and distinct brain activation patterns in the positive emotion group.

The transcriptional and splicing changes caused by hybridization can be globally recovered by genome doubling during allopolyploidization

This study shows that genome doubling in allopolyploids can recover transcriptional and splicing changes from hybridization, partially fixing heterosis and revealing new insights into transcriptome reprogramming mechanisms.

Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives

The paper identifies food and drug additives that inhibit intestinal drug transporters and shows gut bacteria can inactivate these additives, reducing their inhibitory effect.

Desiccation Does Not Drastically Increase the Accessibility of Foreign DNA to the Nuclear Genomes: Evidence from the Frequency of Endosymbiotic DNA Transfer

The paper investigates whether desiccation increases foreign DNA integration into nuclear genomes by analyzing NUMT and NUPT abundance in desiccation-tolerant and sensitive organisms, finding no significant increase.