Author

K. N. Swatek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

I. Wallace· 2 shared A. Clancy· 1 shared B. A. Schulman· 1 shared E. V. Rusilowicz-Jones· 1 shared J. R. Prabu· 1 shared K. Baek· 1 shared M. J. Clague· 1 shared R. Vollrath· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

I. Wallace

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2 papers

Recent·Most cited

ISGylation-independent protection of cell growth by USP18 following interferon stimulation

A. Clancy, E. V. Rusilowicz-Jones, I. Wallace, K. N. Swatek, S. Urbe, M. J. Clague

This study shows USP18 suppresses ISG15 E1 enzyme expression and cell growth inhibition in interferon-stimulated cells independently of its deubiquitylase activity.

bioRxiv · Jul 21, 2023 · PreprintCell Biology

Insights into the ISG15 transfer cascade by the UBE1L activating enzyme

I. Wallace, K. Baek, J. R. Prabu, R. Vollrath, S. von Gronau, B. A. Schulman, K. N. Swatek

This study presents a cryo-EM structure of the UBE1L-UBE2L6 complex bound to ISG15, revealing mechanisms of ISG15 recognition and conjugation pathway specificity.

bioRxiv · Apr 6, 2023Biochemistry