Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade
M. A. Stanczak, N. R. Mantuano, N. Kirchhammer, D. E. Sanin, J. Wang, M. P. Trefny, G. Monaco, M. A. Gray, A. Petrone, A. S. Kashyap, K. Glatz, B. Kasenda, K. Normington, J. Broderick, L. Peng, , H. Laeubli
This study shows that targeting cancer glycosylation with an antibody-sialidase conjugate repolarizes tumor-associated macrophages and enhances immune checkpoint blockade efficacy in mouse models.
bioRxiv · Apr 11, 2021Immunology