G. Monaco

Streptococcal meningoencephalitis dynamically shapes developmental monocyte and macrophage trajectories in the CNS

This study shows that streptococcal meningoencephalitis alters monocyte and macrophage dynamics in the dura by shifting their origin from skull bone marrow to peripheral sources and increasing MDP-Mo-derived cells.

A Community Challenge to Predict Clinical Outcomes After Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

The paper evaluates predictive models for immune checkpoint inhibitor outcomes in NSCLC using clinical trial data from two RCTs, finding that models combining PD-L1, TMB, and immune signatures outperform single biomarkers.

DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response 1 to oxidative stress

This study identifies DNA damage signaling in Drosophila macrophages as a key regulator of cytokine release and oxidative stress response through JNK and unpaired-3.

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade

This study shows that targeting cancer glycosylation with an antibody-sialidase conjugate repolarizes tumor-associated macrophages and enhances immune checkpoint blockade efficacy in mouse models.

Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation

This study shows hyperglycemia promotes cancer immune evasion by increasing O-GlcNAcylation in tumor-associated macrophages, shifting their polarization to a pro-tumorigenic M2-like phenotype.