An endogenous glucocorticoid-cytokine signaling circuit promotes CD8+ T cell dysfunction in the tumor microenvironment
N. Acharya, A. Madi, H. Zhang, M. Klapholz, E. Christian, K. O. Dixon, G. Fell, K. Tooley, D. Mangani, J. Xia, M. Singer, D. Neuberg, O. Rozenblatt-Rosen, A. Regev, V. K. Kuchroo, A. C. Anderson
This study identifies a glucocorticoid-cytokine signaling circuit in the tumor microenvironment that promotes CD8+ T cell dysfunction and correlates with poor response to checkpoint blockade in melanoma.
bioRxiv · Oct 10, 2019 · PreprintImmunology