The novel, recurrent mutation in the TOP2A gene results in the enhanced topoisomerase activity and transcription deregulation in glioblastoma
B. Gielniewski, K. Poleszak, A.-J. Roura, P. Szadkowska, S. K. Krol, R. Guzik, P. Wiechecka, M. Maleszewska, B. Kaza, A. Marchel, T. Czernicki, A. Koziarski, G. Zielinski, A. Styk, M. Kawecki, , B. Kaminska
The paper identifies a novel TOP2A mutation in glioblastomas that enhances DNA binding and transcriptional activity, correlating with poorer patient survival.
bioRxiv · Jun 17, 2020 · PreprintCancer Biology