Author

K. R. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. Moffat· 4 shared A. Khoo· 2 shared A. Nixon· 2 shared C. Chokshi· 2 shared C. Venugopal· 2 shared D. Bakhshinyan· 2 shared N. Savage· 2 shared N. Tatari· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

J. Moffat

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma

M. A. Qazi, S. K. Salim, K. R. Brown, N. Mikolajewicz, N. Savage, H. Han, M. K. Subapanditha, D. Bakhshinyan, A. Nixon, P. Vora, K. Desmond, C. Chokshi, M. Singh, A. Khoo, A. Macklin, , S. K. Singh

This study characterizes the minimal residual disease state in glioblastoma, revealing distinct evolutionary trajectories and immunomodulatory signatures associated with recurrence.

bioRxiv · Jan 28, 2022Cancer Biology

Hitting more birds with one stone: CD70 as an actionable immunotherapeutic target in recurrent glioblastoma

M. Seyfrid, W. Maich, V. M. Shaikh, N. Tatari, D. Upreti, D. Piyasena, M. Subapanditha, N. Savage, D. McKenna, L. Kuhlmann, A. Khoo, S. K. Salim, B. Bassey-Archibong, W. D. Gwynne, C. Chokshi, , S. K. Singh

This study identifies CD70 as a therapeutic target for recurrent glioblastoma, showing that CD70 knockdown reduces tumorigenicity and CD70 CAR-T therapy improves survival in animal models.

bioRxiv · Jun 2, 2021 · PreprintCancer Biology

NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4

P. Jain, A. Dvorkin-Gheva, E. Mollen, M. Xie, F. Jessa, P. Dhavarasa, S. Chung, K. R. Brown, G. H. Jang, F. Notta, J. Moffat, D. Hedley, P. C. Boutros, B. G. Wouters, M. Koritzinsky

This study identifies NOX4 as a link between metabolic deregulation and ER-specific redox vulnerability in PDAC, suggesting PRDX4 as a therapeutic target for pancreatic cancer.

bioRxiv · Oct 8, 2020Cancer Biology

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

C. A. Chang, J. Jen, S. Jiang, A. Sayad, A. S. Mer, K. R. Brown, A. Nixon, A. Dhabaria, K. H. Tang, D. Venet, C. Sotiriou, J. Deng, K.-k. Wong, S. Adams, P. Meyn, , B. G. Neel

This study identifies drug-tolerant persisters (DTPs) in HER2+ breast cancer and reveals their origins and vulnerabilities to TKI resistance.

bioRxiv · Aug 28, 2020Cancer Biology