M. Xie

HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

A neutral process of genome reduction in marine bacterioplankton

The paper investigates genome reduction in marine bacterioplankton, finding that neutral processes like genetic drift, not streamlining selection, drive genome size reduction in the Roseobacter group.

Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron Variants

The paper identifies an antibody with broad neutralization against SARS-CoV-2 Omicron variants and shows how somatic mutations enhance its neutralization breadth and potency.

Transcription Factor Dynamics in Cross-Regulation of Plant Hormone Signaling Pathways

The paper constructs a cross-regulation network of plant hormone signaling pathways by analyzing transcription factor activity and dynamic regulatory models in Arabidopsis seedlings.

StereoSiTE: A framework to spatially and quantitatively profile the cellular neighborhood organized iTME

StereoSiTE analyzes spatial transcriptomics data to identify cell-cell interactions in the tumor microenvironment and reveals neutrophil-driven communication networks in treated xenograft models.

HIV-1 cell-to-cell spread overcomes the virus entry block of non-macrophage-tropic strains in macrophages

This study shows that HIV-1 non-macrophage-tropic strains can infect macrophages through cell-to-cell transfer, overcoming entry block limitations seen in cell-free infection.

An enzyme-based system for the extraction of small extracellular vesicles from plants

This study develops an enzyme-based method to extract plant extracellular vesicles, showing higher yield and therapeutic potential compared to traditional methods.

Exosomal miR-769-5p confers cisplatin resistance and tumorigenesis in gastric cancer

This study identifies exosomal miR-769-5p as a mediator of cisplatin resistance in gastric cancer by targeting CASP9 and promoting apoptosis evasion.

Early megakaryocyte lineage-committed progenitors in adult mouse bone marrow

This study identifies early megakaryocyte lineage-committed progenitors in adult mouse bone marrow and proposes a differentiation model involving intermediate progenitors.

Abortion occurs during double fertilisation and ovule development in Paeonia ludlowii

This study investigates ovule abortion in Paeonia ludlowii, identifying types, developmental stages, and morphological differences between aborted and fertile ovules.

Rectal bacteria produce sex pheromones in the male oriental fruit fly

This study shows that bacteria in the rectum of male oriental fruit flies produce sex pheromones, specifically TMP and TTMP, which attract females.

NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4

This study identifies NOX4 as a link between metabolic deregulation and ER-specific redox vulnerability in PDAC, suggesting PRDX4 as a therapeutic target for pancreatic cancer.

Secondary ossification center induces and protects growth plate structure

This study identifies the secondary ossification center's role in protecting growth plate hypertrophic chondrocytes from mechanical stress during terrestrial adaptation.

Egg-surface bacteria deter oviposition by the oriental fruit fly Bactrocera dorsalis

The paper shows that egg-surface bacteria in Bactrocera dorsalis increase β-caryophyllene in fruits, deterring oviposition by conspecific flies.

Introduction of the Aspergillus fumigatus α-1,2-mannosidase MsdS into Trichoderma reesei leads to abnormal polarity and improves the ligno-cellulose degradation

This study introduces Aspergillus fumigatus α-1,2-mannosidase MsdS into Trichoderma reesei, altering N-glycan processing and improving lignocellulose degradation while causing abnormal polarity and secretion phenotypes.

A genome-wide CRISPR screen reveals a role for the BRD9-containing non-canonical BAF complex in regulatory T cells

This study identifies BRD9-containing non-canonical BAF complex as a regulator of Foxp3 in Tregs using a genome-wide CRISPR screen.

The socioeconomic burden of severe mental disorder in China, 2014-2017: a prevalence study

This study estimates the economic burden of severe mental disorder in China from 2014-2017 using prevalence-based methods, finding substantial direct and indirect costs.