Control of MYC-dependent apoptotic threshold by a co-amplified ubiquitin E3 ligase UBR5
X. Qiao, Y. Liu, M. L. Prada, A. Gupta, A. Jaiswal, M. Sharma, H. M. Haikala, K. Talvinen, L. Yetukuri, J. W. Pylvänäinen, J. Klefström, P. Kronqvist, A. Meinander, T. Aittokallio, V. Hietakangas, , J. Westermarck
This study identifies UBR5 as a novel MYC ubiquitin ligase that regulates MYC protein stability and apoptotic threshold in cancer cells and breast tissue.
bioRxiv · Jan 8, 2019 · PreprintCancer Biology