Author

J. Klefström

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

H. M. Haikala· 2 shared A. Gupta· 1 shared A. Jaiswal· 1 shared A. Meinander· 1 shared E. Peuhu· 1 shared E.-M. Vesilahti· 1 shared H. Al-Akhrass· 1 shared J. Ivaska· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

H. M. Haikala

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Author profile →

2 papers

Recent·Most cited

Sortilin-related receptor is a druggable therapeutic target in breast cancer

H. Al-Akhrass, M. Pietilä, J. Lilja, E.-M. Vesilahti, J. M. Anttila, H. M. Haikala, P. M. Munne, J. Klefström, E. Peuhu, J. Ivaska

This study shows that targeting SorLA with a monoclonal antibody can overcome HER2 resistance in breast cancer, both in vitro and in vivo.

bioRxiv · Mar 9, 2021Cancer Biology

Control of MYC-dependent apoptotic threshold by a co-amplified ubiquitin E3 ligase UBR5

X. Qiao, Y. Liu, M. L. Prada, A. Gupta, A. Jaiswal, M. Sharma, H. M. Haikala, K. Talvinen, L. Yetukuri, J. W. Pylvänäinen, J. Klefström, P. Kronqvist, A. Meinander, T. Aittokallio, V. Hietakangas, , J. Westermarck

This study identifies UBR5 as a novel MYC ubiquitin ligase that regulates MYC protein stability and apoptotic threshold in cancer cells and breast tissue.

bioRxiv · Jan 8, 2019 · PreprintCancer Biology