Evolution of structural dynamics in bilobed proteins
G. Gouridis, Y. Muthahari, M. de Boer, K. Tassis, A. Tsirigotaki, N. Zijlstra, N. Eleftheriadis, R. Xu, M. Zacharias, D. A. Griffith, Y. Sugijo, A. Doemling, S. Karamanou, A. Economou, T. Cordes
The paper investigates how structural dynamics in bilobed proteins evolve, showing that modifications to the structural core enable functional diversification through altered interdomain interactions and substrate specificity.
bioRxiv · Oct 19, 2020 · PreprintBiophysics