Author

N. Zijlstra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 3 Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Organism:bacteria (other)· 2 Assay:proteomics· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1

Frequent Co-Authors

T. Cordes· 5 shared D. A. Griffith· 2 shared E. Lerner· 2 shared G. Gouridis· 2 shared O. Brix· 2 shared A. Doemling· 1 shared A. Economou· 1 shared A. Guskov· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersBiophysics

T. Cordes

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Conserved Lysine in transmembrane helix 5 is key for the inner gating of the LAT transporter BasC

J. Fort, A. Nicolas-Arago, L. Maggi, M. Martinez-Molledo, D. Kapiki, N. Zijlstra, S. Bodoy, E. Pardon, J. Steyaert, O. Llorca, M. Orozco, T. Cordes, M. Palacin

This study identifies a conserved lysine in TM5 of BasC as critical for cytoplasmic gate dynamics, showing its role in gating transitions and modulation by substrates and mutations.

bioRxiv · Mar 26, 2024 · PreprintBiochemistry

Single-molecule detection and super-resolution imaging with a portable and adaptable 3D-printed microscopy platform (Brick-MIC)

G. G. Moya Munoz, O. Brix, P. Klocke, P. D. Harris, J. R. Luna Piedra, N. D. Wendler, E. Lerner, N. Zijlstra, T. Cordes

The paper introduces Brick-MIC, an affordable, open-source 3D-printed microscopy platform that enables single-molecule and super-resolution imaging techniques.

bioRxiv · Dec 29, 2023Biophysics

Dissecting Mechanisms of Ligand Binding and Conformational Changes in the Glutamine-Binding Protein

Z. Han, S. Panhans, S. Brameyer, E. Bilgen, M. Ram, A. Herr, A. Narducci, M. Isselstein, P. Harris, O. Brix, P. Con, K. Jung, D. C. Lamb, E. Lerner, D. Griffith, , T. Cordes

This study investigates the ligand binding mechanism of GlnBP in E. coli, finding that conformational changes and ligand binding are correlated, and that the induced-fit mechanism is more consistent with the data than conformational selection.

bioRxiv · Aug 2, 2023Biophysics

Enabling spectrally resolved single-molecule localization microscopy at high emitter densities

K. J. A. Martens, M. Gobes, E. Archontakis, R. R. Brillas, N. Zijlstra, L. Albertazzi, J. Hohlbein

This paper presents a low-cost sSMLM implementation that improves spatio-spectral resolution and emitter density using a transmission grating and provides analysis tools.

bioRxiv · Jun 29, 2022Biophysics

Structural and biophysical characterization of the tandem substrate-binding domains of the ABC importer GlnPQ

E. Ploetz, G. Schuurman-Wolters, N. Zijlstra, A. Jager, D. A. Griffith, A. Guskov, G. Gouridis, B. Poolman, T. Cordes

This paper characterizes the structural and biophysical properties of the tandem substrate-binding domains of the ABC importer GlnPQ using crystal structures, calorimetry, and smFRET.

bioRxiv · Dec 19, 2020Biophysics

Evolution of structural dynamics in bilobed proteins

G. Gouridis, Y. Muthahari, M. de Boer, K. Tassis, A. Tsirigotaki, N. Zijlstra, N. Eleftheriadis, R. Xu, M. Zacharias, D. A. Griffith, Y. Sugijo, A. Doemling, S. Karamanou, A. Economou, T. Cordes

The paper investigates how structural dynamics in bilobed proteins evolve, showing that modifications to the structural core enable functional diversification through altered interdomain interactions and substrate specificity.

bioRxiv · Oct 19, 2020 · PreprintBiophysics