Author

K. Thalassinos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Casamento· 1 shared A. Cryar· 1 shared A. Hatimy· 1 shared A. J. Hickey· 1 shared A. P. A. Ferreira· 1 shared B. Maertens· 1 shared C. A. Orengo· 1 shared C. L. Hall· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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1 shared paperCell Biology

A. Casamento

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Modeling flexible protein structure with AlphaFold2 and cross-linking mass spectrometry

K. Manalastas-Cantos, K. R. Adoni, M. Pfeifer, B. Maertens, K. Grunewald, K. Thalassinos, M. Topf

The paper introduces a pipeline combining AlphaFold2 and XL-MS to model protein conformations, showing improved accuracy in identifying correct structures using new scores.

bioRxiv · Sep 11, 2023Biochemistry

Structural basis of substrate progression through the chaperonin cycle

S. Gardner, M. C. Darrow, N. Lukoyanova, K. Thalassinos, H. R. Saibil

The paper uses cryoEM to determine structures of GroEL-GroES complexes with Rubisco, revealing conformational changes and interactions during the chaperonin cycle.

bioRxiv · May 29, 2023 · PreprintBiophysics

The ataxia protein sacsin is required for integrin trafficking and synaptic organization

L. E. L. Romano, W. Y. Aw, K. M. Hixson, T. V. Novoselova, T. M. Havener, S. Howell, C. L. Hall, L. Xing, J. Beri, S. Nethisinghe, L. Perna, A. Hatimy, G. Chioccioli Altadonna, L. M. Graves, L. E. Herring, , J. M. Wolter

This study identifies sacsin's role in integrin trafficking and synaptic organization, showing its deficiency causes cellular phenotypes in ARSACS.

bioRxiv · Aug 20, 2021 · PreprintCell Biology

Intermittent Bulk Release of Human Cytomegalovirus

F. J. Flomm, T. K. Soh, C. Schneider, L. Wedemann, H. M. Britt, K. Thalassinos, S. Pfitzner, R. Reimer, K. Gruenewald, J. B. Bosse

This study identifies a novel HCMV egress pathway involving intermittent bulk release of virions from multiviral bodies.

bioRxiv · Dec 31, 2020Microbiology

Cdk5 and GSK3β inhibit Fast Endophilin-Mediated Endocytosis

A. P. A. Ferreira, A. Casamento, S. Carrillo Roas, J. Panambalana, S. Subramaniam, K. Schuetzenhofer, E. F. Halff, L. Cha Wah Hak, K. McGourty, J. Kittler, K. Thalassinos, D. Martinvalet, E. Boucrot

This study identifies Cdk5 and GSK3β as negative regulators of fast Endophilin-mediated endocytosis, showing they suppress the pathway by affecting protein interactions and cargo sorting.

bioRxiv · Apr 11, 2020Cell Biology

Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila

H. M. Scholes, A. Cryar, F. Kerr, D. Sutherland, L. A. Gethings, J. P. C. Vissers, J. G. Lees, C. A. Orengo, L. Partridge, K. Thalassinos

The paper tracks proteomic changes in Drosophila with Aβ42 pathology and identifies proteins associated with AD processes.

bioRxiv · Jul 8, 2019Biochemistry