Author

A. J. Hickey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:mouse· 1

Frequent Co-Authors

W. Y. Aw· 2 shared A. H. Cooper· 1 shared A. Hatimy· 1 shared A. MacNeil· 1 shared A. Schaefer· 1 shared A. V. Kabanov· 1 shared A. Walz· 1 shared B. Griffith· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBioengineering

W. Y. Aw

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A Modified BPaL Regimen for Tuberculosis Treatment replaces Linezolid with Inhaled Spectinamides

M. Zohaib Ali, T. S. Dutt, A. MacNeil, A. Walz, J. Patterson, C. Pearce, H. Lam, J. S. Philp, R. Lee, J. Liu, G. T. Robertson, A. J. Hickey, B. Meibohm, M. Gonzalez-Juarrero

This paper evaluates a modified BPaL regimen replacing linezolid with inhaled spectinamide 1599 for tuberculosis treatment, showing similar efficacy while avoiding linezolid-associated adverse events.

bioRxiv · Nov 16, 2023Microbiology

Microphysiological vascular malformation model reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation.

W. Y. Aw, C. Cho, H. Wang, A. H. Cooper, E. L. Doherty, D. Rocco, S. A. Huang, S. Kubik, C. P. Whitworth, R. Armstrong, A. J. Hickey, B. Griffith, M. L. Kutys, J. Blatt, W. J. Polacheck

The paper develops a microfluidic model of PIK3CA-driven vascular malformations and identifies dysregulated Rac1/PAK and mTORC1/2 signaling as key factors in lesion formation.

bioRxiv · Sep 3, 2022 · PreprintBioengineering

Stable nebulization and muco-trapping properties of Regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19

M. D. McSweeney, I. Stewart, Z. Richardson, H. Kang, Y. Park, C. Kim, K. Tiruthani, W. Wolf, A. Schaefer, P. Kumar, H. Aurora, J. Hutchins, J. M. Cho, A. J. Hickey, S. Y. Lee, S. K. Lai

This paper demonstrates that IN-006, a reformulated Regdanvimab, effectively traps SARS-CoV-2 virus-like particles in human airway mucus and achieves higher lung concentrations in rats when nebulized compared to intravenous delivery.

bioRxiv · Feb 27, 2022Bioengineering

Nanoformulated Remdesivir with Extremely Low Content of Poly(2-oxazoline) - Based Stabilizer for Aerosol Treatment of COVID-19

J. D. Ramsey, I. E. Stewart, E. A. Madden, C. Lim, D. Hwang, M. T. Heise, A. J. Hickey, A. V. Kabanov

bioRxiv · Jan 21, 2022Bioengineering

The ataxia protein sacsin is required for integrin trafficking and synaptic organization

L. E. L. Romano, W. Y. Aw, K. M. Hixson, T. V. Novoselova, T. M. Havener, S. Howell, C. L. Hall, L. Xing, J. Beri, S. Nethisinghe, L. Perna, A. Hatimy, G. Chioccioli Altadonna, L. M. Graves, L. E. Herring, , J. M. Wolter

This study identifies sacsin's role in integrin trafficking and synaptic organization, showing its deficiency causes cellular phenotypes in ARSACS.

bioRxiv · Aug 20, 2021 · PreprintCell Biology