Author

Y. You

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Immunology· 3 Cell Biology· 2 Ecology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Organism:human· 8 Research Focus:host-pathogen & immune response· 6 Approach:statistical model· 6 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:ecology & biodiversity· 4 Research Focus:gene regulatory network inference· 4

Frequent Co-Authors

J. Zhang· 3 shared L. Li· 3 shared P. Kerner· 3 shared A. Mirkouei· 2 shared E. Struhs· 2 shared H. Wang· 2 shared J. Li· 2 shared J. Wang· 2 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCancer Biology

J. Zhang

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19 papers

Recent·Most cited

Biochar Modulates Wheat Root Metabolome and Rhizosphere Microbiome in a Feedstock-dependent Manner

H. Yang, P. Kerner, X. Liang, E. Struhs, A. Mirkouei, Y. You

This study investigates how different biochar feedstocks affect wheat root metabolome and rhizosphere microbiome, finding that feedstock type has a greater impact than application rate.

bioRxiv · Jul 17, 2024 · PreprintMicrobiology

Optimization of gene knockout approaches and practical solutions to sgRNA selection challenges in hPSCs with inducible Cas9 system

J. Ni, J. Gong, Y. Ran, R. Bai, P. Huang, M. Zhou, Z. Zheng, Y. You, F. Lan, X. Liu

This study optimizes gene knockout in hPSCs using an inducible Cas9 system and identifies effective sgRNAs by comparing experimental results with cleavage efficiency algorithms.

bioRxiv · Jul 9, 2024 · PreprintCell Biology

Early-life Microbiome-Derived HCA Enhances Type 3 Immunity via FXR-dependent m6A RNA methylation

z. yang, Z. Lin, Y. You, M. Zhang, N. Gao, X. Wang, J. Peng, H. Wei

bioRxiv · Jul 4, 2024 · PreprintMicrobiology

Reduction of chemokine CXCL9 expression by omega-3 fatty acids via ADP-ribosylhydrolase ARH3 in MIN6 insulin-producing cells

Y. You, S. Sarkar, C. Deiter, E. Elliott, C. Nicora, R. Mirmira, L. Sussel, E. Nakayasu

This study shows omega-3 fatty acids reduce CXCL9 expression in MIN6 cells via ARH3, potentially protecting beta cells from immune attack and preventing T1D.

bioRxiv · Jan 30, 2024Cell Biology

Unraveling the role of γδ T cells in the pathogenesis of an oncogenic avian herpesvirus

M. A. Sabsabi, A. Kheimar, Y. You, D. von La Roche, S. Härtle, T. W. Göbel, T. von Heyl, B. Schusser, B. B. Kaufer

This study shows that γδ T cells restrict Marek's disease virus replication and tumor formation in chickens by reducing viral load in key lymphoid organs.

bioRxiv · Dec 5, 2023Microbiology

Microbial Responses to Biochar Soil Amendment and Influential Factors: A Three-level Meta-analysis

P. Kerner, E. Struhs, A. Mirkouei, K. Aho, K. A. Lohse, R. S. Dungan, Y. You

This study meta-analyzes 61 studies to assess how biochar affects soil microbes, finding significant impacts on microbial abundance and enzyme activity, with key factors like feedstock and pH influencing responses.

bioRxiv · Jun 2, 2023Ecology

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell Lines

M. Wu, R. Yuan, N. Ji, T. Lu, T. Wang, J. Zhang, M. Li, P. Cao, J. Zhao, G. Li, J. Li, Y. Li, Y. Tang, Z. Gao, X. Wang, , J. Chen

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

bioRxiv · Feb 20, 2023 · PreprintCancer Biology

Establishment of cell transcriptional identity during seed germination

L. C. Liew, Y. You, M. Oliva, M. Peirats-Llobet, S. Ng, M. Tamiru-Oli, O. G. Berkowitz, U. V. T. Hong, A. Haslem, T. Stuart, M. E. Ritchie, G. Bassel, R. Lister, J. Whelan, Q. Gouil, M. G. Lewsey

This study maps the temporal changes in cell-type specific gene expression during Arabidopsis seed germination, revealing a shared initial transcriptional state followed by distinct regulatory programs.

bioRxiv · Jan 21, 2023 · PreprintPlant Biology

Differential effects of carbon nanotube and graphene on the tomato rhizosphere microbiome

Y. You, P. Kerner, S. Shanmugam, M. V. Khodakovskaya

This study compares the effects of carbon nanotubes and graphene on tomato rhizosphere microbiomes, finding that CNTs increase microbial diversity and alter community functions more than graphene.

bioRxiv · Nov 10, 2022 · PreprintMicrobiology

CIS calibrates GM-CSF signalling strength to regulate macrophage polarization via a STAT5-IRF8 axis

s. zhang, J. Rautela, N. G. Bediaga, T. Kolesnik, Y. You, L. Dagley, J. Bedo, H. Wang, L. Sun, R. Sutherland, E. Surgenor, N. Iannarella, R. S. Allan, F. Souza-Fonseca-Guimaraes, Y. Xie, , Y. Zhan

This study identifies CIS as a regulator of GM-CSF signaling that controls macrophage polarization via the STAT5-IRF8 axis, influencing immune responses and allergic inflammation.

bioRxiv · Mar 31, 2022 · PreprintImmunology

Comparative transcriptomics unveil distinctive metabolic pathway of phosphonate utilization by diatom Phaeodactylum tricornutum

H. Shu, Y. You, H. Wang, J. Wang, L. Li, X. Lin, J. Ma

This study identifies a unique phosphonate utilization mechanism in diatom Phaeodactylum tricornutum involving uptake via clathrin-mediated endocytosis and incorporation into membrane phospholipids.

bioRxiv · Feb 9, 2022 · PreprintMicrobiology

Genomic differentiation within East Asian Helicobacter pylori

Y. You, K. Thorell, L. He, K. Yahara, Y. Yamaoka, J.-H. Cha, K. Murakami, Y. Katsura, TEAMHp, I. Kobayashi, D. Falush, J. Zhang

This study identifies genomic differentiation in Helicobacter pylori across East Asia, linking specific SNPs to cancer risk and geographic adaptation.

bioRxiv · Jun 5, 2021Microbiology

Essential Role of Placenta Derived Interferon Stimulated Gene 20 Against ZIKA Virus Infection

J. Ding, P. Aldo, C. M. Roberts, P. R. Stabach, H. Liu, Y. You, X. Qiu, J. Jeong, A. Maxwell, B. D. Lindenbach, D. T. Braddock, A. Liao, M. Gil

This study identifies ISG20 as a key antiviral factor against Zika virus in trophoblast cells and demonstrates the therapeutic potential of recombinant ISG20-Fc protein.

bioRxiv · Jan 13, 2021Immunology

The Biogeography of Fungal Communities Across Different Chinese Wine-producing Regions Associated with Environmental Factors and Spontaneous Fermentation Performance

R. Li, S. Yang, M. Lin, S. Guo, X. Han, M. Ren, L. Du, Y. Song, Y. You, J. Zhan, W. Huang

This study analyzes fungal communities in Chinese Marselan wine fermentation across regions, finding that environmental factors significantly influence fungal composition and fermentation performance.

bioRxiv · Oct 22, 2020Microbiology

Longitudinal single-cell immune profiling revealed distinct innate immune response in asymptomatic COVID-19 patients

X.-N. Zhao, Y. You, G.-L. Wang, H.-X. Gao, X.-M. Cui, L.-J. Duan, S.-B. Zhang, Y.-L. Wang, L. Yao, L. Li, J.-H. Lu, H.-B. Wang, J.-F. Fan, H.-W. Zheng, E.-H. Dai, , M.-J. Ma

The paper profiles longitudinal single-cell immune responses in asymptomatic COVID-19 patients and identifies distinct innate immune features associated with asymptomatic disease.

bioRxiv · Sep 2, 2020Immunology

One enzyme many faces: alkaline phosphatase-based phosphorus-nutrient strategies and the regulatory cascade revealed by CRISPR/Cas9 gene knockout

K. Zhang, Z. Zhou, J. Wang, J. Li, X. Lin, L. Li, X. Wu, Y. You, S. Lin

The paper uses CRISPR/Cas9 to study alkaline phosphatase isoforms and their regulatory network in diatoms, revealing their functional differences and compensatory roles in phosphorus scavenging.

bioRxiv · May 20, 2020 · PreprintEcology

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

S. Brouwer, T. C. Barnett, D. Ly, K. J. Kasper, D. M. De Oliveira, T. Rivera-Hernandez, A. J. Cork, L. McIntyre, M. G. Jespersen, J. Richter, B. L. Schulz, G. Dougan, V. Nizet, K.-Y. Yuen, Y. You, , M. J. Walker

This study identifies prophage-encoded exotoxins in Streptococcus pyogenes that enhance colonization fitness and pathogenesis in scarlet fever.

bioRxiv · May 17, 2020Microbiology

Testosterone Changes in Female Pandas in Estrus

X. Liu, L. Yuan, W. Wang, Y. You, Y. Liu, T. Ma, Z. Wang, X. Jin, Q. Ma, Y. Lu, J. Zhang, S. Zhao

This study examines testosterone level changes in female giant pandas during estrus and finds that testosterone peaks 4 days after estradiol peaks and is only correlated with estradiol after the estradiol peak.

bioRxiv · Dec 3, 2019 · PreprintZoology

Proteomic and Biological Profiling of Extracellular Vesicles from Alzheimer’s Disease Human Brain Tissues

S. Muraoka, A. M. DeLeo, M. K. Sethi, K. Yukawa-Takamatsu, Z. Yang, J. Ko, J. D. Hogan, Z. Ruan, Y. You, Y. K. Wang, M. Medalla, S. Ikezu, W. Xia, S. Gorantla, H. E. Gendelman, , T. Ikezu

The paper profiles proteomic and biological features of extracellular vesicles from Alzheimer’s disease and control brain tissues, identifying new signature proteins associated with AD.

bioRxiv · Aug 15, 2019Biochemistry