Y. Yamaoka

An ancient ecospecies of Helicobacter pylori found in Indigenous populations and animal adapted lineages.

The paper identifies a new ecospecies of Helicobacter pylori, 'Hardy', found in Indigenous populations and animal-adapted lineages, with distinct genetic features and evolutionary history.

Evaluation of heat inactivation of human norovirus in freshwater clams using human intestinal enteroids

This study evaluates heat inactivation of human norovirus in freshwater clams using human intestinal enteroids, finding that 1 minute at 90°C inactivates the virus.

Dasabuvir inhibits human norovirus infection in human intestinal enteroids

This study identifies dasabuvir as an anti-HuNoV inhibitor using human intestinal enteroids, showing activity against HuNoV, SARS-CoV-2, and RVA.

Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations

This study shows H. pylori has spread repeatedly from Africa by replacing strains with deleterious mutations through migration and selection.

Genomic differentiation within East Asian Helicobacter pylori

This study identifies genomic differentiation in Helicobacter pylori across East Asia, linking specific SNPs to cancer risk and geographic adaptation.

Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory amino acid differences and novel oncoprotein candidates

This study uses GWAS to identify genetic variations in H. pylori strains associated with gastric cancer and duodenal ulcers, revealing amino acid differences and novel oncoprotein candidates.

Helicobacter small RNA regulates host adaptation and carcinogenesis

This study identifies HPnc4160, a small RNA in H. pylori, that negatively regulates host adaptation and gastric cancer by modulating gene expression and bacterial colonization.