A stromal-state dichotomy governs recalcitrance or remission in inflammatory bowel disease
Courtney Tindle, Harrison M. Penrose, Saptarshi Sinha, Madhubanti Mullick, Kennith Carpio-Perkins, Mason Hayashi, Sophia Carpinelli, Ella McLaren, Chia-Chian Hsieh, Kameron M. Zablan, Helen N. Le, Jennifer Neill, Gajanan Dattatray Katkar, W Sandborn, Brigid Sweeney Boland, Pradipta Ghosh
This paper identifies two stromal states in IBD that predict clinical outcomes and shows that targeting one state can reverse disease pathology.
bioRxiv · Jun 13, 2026 · PreprintPhysiology