Author

Sinclair Williams

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Celia R. Espinoza· 1 shared Courtney TindleiD· 1 shared David Chen· 1 shared Gajanan Dattatray KatkariD· 1 shared Irina KufarevaiD· 1 shared Jane YangiD· 1 shared Jasmin Salem· 1 shared Kameron M. Zablan· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Celia R. Espinoza

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

A NOD2-Encoded Toggle Switch Resolves the Host-Microbe Battle Over Cyclic AMP Control

Mahitha Shree Anandachar, David Chen, Kennith Carpio-Perkins, Gajanan Dattatray Katkar, Suchismita Roy, Celia R. Espinoza, Madhubanti Mullick, Saptarshi Sinha, Michelle Nakayama, Jasmin Salem, Megan L. Estanol, Rishav Bhattacharjee, Kameron M. Zablan, S. Hsu, Sinclair Williams, , Pradipta Ghosh

This paper identifies a host-encoded toggle switch involving NOD2 and GIV that controls cAMP levels in macrophages, converting tolerant cells into microbicidal machines to restore microbial clearance and gut barrier integrity.

bioRxiv · Mar 31, 2026 · PreprintImmunology