Author

Megan L. Estanol

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Celia R. Espinoza· 3 shared Gajanan Dattatray KatkariD· 3 shared Madhubanti MullickiD· 3 shared Mahitha Shree AnandachariD· 3 shared Pradipta GhoshiD· 3 shared Saptarshi SinhaiD· 3 shared Ella McLareniD· 2 shared Kennith Carpio-Perkins· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Celia R. Espinoza

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Druggable G Protein Checkpoint in Cholesterol Efflux

Gajanan Dattatray Katkar, Mahitha Shree Anandachar, Celia R. Espinoza, Megan L. Estanol, Caroline Biggs, Michelle Nacayama, Shu-Tsing Hsu, Ellie Tam, Raktim Mukharjee, Ella McLaren, Stephanie Aviles, Vanessa Castillo, Yashaswat S. Malhotra, Madhubanti Mullick, Armando Aaron, , Pradipta Ghosh

The paper identifies GIV as a macrophage checkpoint suppressing reverse cholesterol transport and shows its inhibition restores cholesterol efflux, reducing plaque burden and systemic lipid overload.

bioRxiv · Jun 24, 2026 · PreprintImmunology

A NOD2-Encoded Toggle Switch Resolves the Host-Microbe Battle Over Cyclic AMP Control

Mahitha Shree Anandachar, David Chen, Kennith Carpio-Perkins, Gajanan Dattatray Katkar, Suchismita Roy, Celia R. Espinoza, Madhubanti Mullick, Saptarshi Sinha, Michelle Nakayama, Jasmin Salem, Megan L. Estanol, Rishav Bhattacharjee, Kameron M. Zablan, S. Hsu, Sinclair Williams, , Pradipta Ghosh

This paper identifies a host-encoded toggle switch involving NOD2 and GIV that controls cAMP levels in macrophages, converting tolerant cells into microbicidal machines to restore microbial clearance and gut barrier integrity.

bioRxiv · Mar 31, 2026 · PreprintImmunology

Distinct Colitis-Associated Macrophages Drive NOD2-Dependent Bacterial Sensing and Gut Homeostasis

Gajanan Dattatray Katkar, Mahitha Shree Anandachar, Stella‐Rita Ibeawuchi, Ella McLaren, Megan L. Estanol, Kennith Carpio-Perkins, S. Hsu, Celia R. Espinoza, Jane Coates, Yashaswat S. Malhotra, Madhubanti Mullick, Vanessa Castillo, Daniella T. Vo, Saptarshi Sinha, Pradipta Ghosh

The paper identifies niColAMs as critical for IBD recovery and shows GIV-NOD2 interaction is essential for microbial sensing and gut homeostasis.

Journal of Clinical Investigation · Oct 2, 2025Peer-reviewedImmunology