Author

Karen E. Brown

Hammersmith Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Amanda G. FisheriD· 3 shared Andrew DimondiD· 3 shared Bhavik PateliD· 3 shared Chad Whilding· 3 shared Sherry J. CheriyamkunneliD· 3 shared Alex MontoyaiD· 2 shared Do Hyeon GimiD· 2 shared Dounia DjeghlouliD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Amanda G. FisherORCID

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Author profile →

3 papers

Recent·Most cited

Individual mouse mitotic chromosomes exhibit cell type-specific differences in biomechanical properties

Karen E. Brown, Shubhadeep Patra, Andrew Dimond, Korak Kumar Ray, Sherry J. Cheriyamkunnel, Bhavik Patel, Do Hyeon Gim, Chad Whilding, Marta Llobet Ayala, Mehmet Efe Kilic, David Rueda, Amanda G. Fisher

The paper shows that mouse metaphase chromosomes from different cell types have distinct biomechanical properties, with ESC-derived chromosomes showing conserved force-dependent responses but differing from those of NSCs and preB cells.

bioRxiv · Sep 10, 2026 · PreprintBiophysics

PBK/TOPK mediates Ikaros, Aiolos and CTCF displacement from mitotic chromosomes and alters chromatin accessibility at selected C2H2-zinc finger protein binding sites

Andrew Dimond, Do Hyeon Gim, Elizabeth Ing‐Simmons, Chad Whilding, Holger Kramer, Dounia Djeghloul, Alex Montoya, Bhavik Patel, Sherry J. Cheriyamkunnel, Karen E. Brown, Pavel V. Shliaha, Juan M. Vaquerizas, Matthias Merkenschlager, Amanda G. Fisher

The paper shows PBK/TOPK phosphorylates Ikaros, Aiolos, and CTCF to displace them from mitotic chromosomes, altering chromatin accessibility at specific zinc finger protein sites.

bioRxiv · Apr 23, 2024 · PreprintMolecular Biology

Loss of H3K9 tri-methylation alters chromosome compaction and transcription factor retention during mitosis

Dounia Djeghloul, Andrew Dimond, Sherry J. Cheriyamkunnel, Holger Kramer, Bhavik Patel, Karen E. Brown, Alex Montoya, Chad Whilding, Yi-Fang Wang, Matthias Erwin Futschik, Nicolás Veland, Thomas Montavon, Thomas Jenuwein, Matthias Merkenschlager, Amanda G. Fisher

The paper shows that loss of H3K9 tri-methylation leads to smaller, more compact mitotic chromosomes and altered transcription factor retention.

Nature Structural & Molecular Biology · Mar 20, 2023Peer-reviewedMolecular Biology