Elizabeth Ing‐Simmons

This study creates a single-nucleus multiomic and spatial atlas of human spermatogenesis, linking gene regulatory networks to infertility-associated genetic variation and disease perturbations.

The paper shows PBK/TOPK phosphorylates Ikaros, Aiolos, and CTCF to displace them from mitotic chromosomes, altering chromatin accessibility at specific zinc finger protein sites.

The paper confirms that SSIM depends on Hi-C matrix properties and provides improved methods for identifying differential 3D genome conformation.

The paper shows that 3D chromatin organisation and gene regulation are independent during Drosophila dorsoventral patterning, with chromatin structure maintaining consistency across tissues despite differences in gene expression.