ZFP462 targets heterochromatin to transposon-derived enhancers restricting transcription factor binding and expression of lineage-specifying genes
Ramesh Yelagandula, Karin Stecher, Maria Novatchkova, Luca Michetti, Georg Michlits, Jingkui Wang, Pablo Hofbauer, Carina Pribitzer, Gintautas Vainorius, Luke Isbel, Sasha Mendjan, Dirk Schübeler, Ulrich Elling, Julius Brennecke, Oliver Bell
This study identifies ZFP462's role in restricting endodermal gene expression by targeting transposon-derived enhancers and modulating histone methylation in mouse embryonic stem cells.
bioRxiv · Jun 28, 2021 · PreprintGenetics