Ulrich Elling

Temporal control of sgRNA library activation unlocks large-scale in vivo CRISPR screens

This paper introduces CRISPR-StAR, an in vivo CRISPR screening platform with improved normalization and analysis tools, showing it can identify tumor suppressor gene effects not observable in vitro.

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance

This study identifies riboflavin as a modulator of ferroptosis sensitivity by supporting FSP1 stability and antioxidant recycling, with implications for therapeutic targeting.

Proteome-scale tagging and functional screening in mammalian cells by ORFtag

ORFtag enables proteome-scale tagging and functional screening in mammalian cells, identifying known and novel regulators of transcription and post-transcriptional processes.

Targeted CRISPR-Cas9 screening identifies transcription factor network controlling murine haemato-endothelial fate commitment

The paper identifies transcription factors and chromatin regulators critical for haemato-endothelial mesoderm formation using CRISPR-Cas9 screens in mouse embryonic stem cells.

Loss of Cohesin regulator PDS5A reveals repressive role of Polycomb loops

The paper identifies PDS5A as a cohesin regulator linking Polycomb silencing and 3D genome organization, showing that its loss disrupts cohesin activity and Polycomb loops without affecting repressive chromatin marks.

Single-cell brain organoid screening identifies developmental defects in autism

The paper uses CRISPR and single-cell transcriptomics to screen ASD risk genes in brain organoids, identifying developmental defects and regulatory modules linked to autism.

The HUSH complex controls brain architecture and protocadherin fidelity

This study identifies the HUSH complex as an epigenetic regulator of protocadherin expression in neurons, affecting brain development and neuronal diversity in mice and humans.

Stem cell specific interferon stimulated gene expression is regulated by the formative pluripotency network through IRF1

The paper shows that Irf1, controlled by the formative pluripotency network, regulates ISG expression and Oct6 in formative pluripotent cells.

A BTB-DOMAIN TRANSCRIPTION FACTOR RECRUITS CHROMATIN REMODELERS AND A HISTONE CHAPERONE DURING THE EXIT FROM PLURIPOTENCY

This study identifies ZBTB2 as a btb-domain transcription factor that recruits chromatin remodelers and a histone chaperone during exit from pluripotency, revealing shared and unique functions of the btb-TF family.

ZFP462 targets heterochromatin to transposon-derived enhancers restricting transcription factor binding and expression of lineage-specifying genes

This study identifies ZFP462's role in restricting endodermal gene expression by targeting transposon-derived enhancers and modulating histone methylation in mouse embryonic stem cells.

The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

The paper identifies lnc-NR2F1 as a pro-neurogenic lncRNA mutated in neurodevelopmental disorders through genetic and functional studies.

Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

This study identifies the Gatad2a-Chd4-Mbd3 subcomplex of the NuRD complex as a key inhibitor of naive pluripotency, showing that its disruption enables deterministic reprogramming of somatic cells to iPSCs.