Natural variation in gene expression and Zika virus susceptibility revealed by villages of neural progenitor cells
Michael F. Wells, James C. Nemesh, Sulagna Dia Ghosh, Jana M. Mitchell, Curtis J. Mello, Daniel Meyer, Kavya Raghunathan, Matthew Tegtmeyer, Derek Hawes, Anna Neumann, Kathleen A. Worringer, Joseph J. Raymond, Sravya Kommineni, Karrie Chan, Daniel J. Ho, , Steven A. McCarroll
The paper identifies a common genetic variant in IFITM3 that explains most inter-individual variation in neural progenitor cell susceptibility to Zika virus using natural genetic variation and synthetic perturbations.
bioRxiv · Nov 8, 2021 · PreprintGenomics