Inflammation and autophagy dysfunction in metachromatic leukodystrophy: a central role for mTOR?
Zoe Catchpole, Annabelle E. Hartanto, Tetsushi Kataura, Paweł Palmowski, Andrew Porter, Emma Foster, Kristina Ulicna, Angela Pyle, Robert William Taylor, Kate S. Harris, Viktor I. Korolchuk, Daniel Erskine
This study identifies inflammation and autophagy dysfunction, linked to mTOR pathway activation, as key mechanisms in metachromatic leukodystrophy using postmortem tissue analysis.
bioRxiv · Sep 14, 2023 · PreprintNeuroscience