GCNA interacts with Spartan and Topoisomerase II to regulate genome stability.
Gregoriy A. Dokshin, Gregory M. Davis, Ashley Sawle, Matthew Eldridge, Peter K. Nicholls, Taylin E. Gourley, Katherine A. Romer, Luke W. Molesworth, Hannah R. Tatnell, Ahmet Rasit Ozturk, Dirk G. de Rooij, Gregory J. Hannon, David C. Page, Craig C. Mello, Michelle A. Carmell
The paper shows GCNA interacts with Topoisomerase II to resolve DNA-protein crosslinks, maintaining genome stability in germline and early embryos.
Developmental Cell · Dec 12, 2019Peer-reviewedDevelopmental Biology