Selective Pyroptosis in NF1-Deficient Cells through PKCδ Agonism
Liang Hu, Yuting Tang, Yuan Lin, Jay Pundavela, Katherine C Scheffer, Abby Schaeper, Tilat A. Rizvi, Jianqiang Wu, Yi Zheng, Nancy Ratner
This study identifies PKCδ agonism as a method to selectively induce pyroptosis in NF1-deficient cells by targeting KRAS-GDP interactions.
bioRxiv · May 21, 2026 · PreprintCancer Biology