Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination
Pietro Berico, Cody L. Dunton, Luay Matthew Almassalha, Amanda Flores Yanke, Karla Medina, Nicolas Acosta, Tara Muijlwijk, Catherine Do, Soobeom Lee, Sharon N. Edmiston, David L. Corcoran, Allison Reiner, Caroline E. Kostrzewa, Kathy Dorsey, Milad Ibrahim, , Eva Hernando
This study shows that chromatin architecture and physical constriction together drive phenotype switching and metastasis in melanoma by altering CTCF positioning and heterochromatin structure.
bioRxiv · Mar 20, 2026 · PreprintCancer Biology