A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype
Wansang Cho, Jenny Y Liu, Alexandra Beckett, Judith C. Lunger, Peng Xu, Katie Ho, Ethan E. Chen, Antonio Salcido-Alcántar, Lucas E. Sant’Anna, Kamal Obbad, Nakoa Po, Elena Sotillo, Crystal Lee Mackall, Kyle G. Daniels
This paper shows how recombining signaling motifs creates a continuous spectrum of CAR T cell phenotypes, revealing trade-offs between memory, cytotoxicity, and safety.
bioRxiv · Jun 5, 2025 · PreprintSynthetic Biology