Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors
Paul Dembny, Andrew G. Newman, Manvendra Singh, Michael Hinz, Michal Szczepek, Christina Krüger, Róbert Adalbert, Omar Dildar a Dzaye, Thorsten Trimbuch, Thomas E. Wallach, Gunnar Kleinau, Katja Derkow, Bernhard Clemens Richard, Carola G. Schipke, Claus Scheidereit, , Seija Lehnardt
This study shows HERV-K(HML-2) RNA activates TLR8 and Tlr7, causing neurodegeneration in mice and correlating with AD in humans.
JCI Insight · Apr 8, 2020Peer-reviewedNeuroscience