Targeting Regnase-1 unleashes CAR T cell antitumor activity for osteosarcoma and creates a proinflammatory tumor microenvironment
Adeleye Oluwatosin Adeshakin, Hao Shi, S. Scott Perry, Heather Sheppard, Phuong Nguyen, Xiang Sun, Peipei Zhou, Jean‐Yves Métais, Trevor J. Cunningham, Kaveri Anil, Liqing Tian, Vivek S. Peche, Mollie S. Prater, Deanna M. Langfitt, Shondra M. Pruett‐Miller, , Stephen M Gottschalk
This study shows that deleting Regnase-1 in CAR T cells enhances their antitumor activity against osteosarcoma by creating a proinflammatory tumor microenvironment.
bioRxiv · May 20, 2025 · PreprintImmunology