The UV potentiated mutational signature of clinical stage G-quadruplex binder CX5461.
Elena Zaikova, Damian Yap, Armaghan Sarvar, Auden Hafezi, Jay Tan, Viviana Cerda, Kaylee Li, Daniel Lai, Karen A. Gelmon, John Frederick Hilton, Lesley Seymour, Peter C. Stirling, Dave W. Cescon, Samuel A. J. R. Aparicio
The paper investigates the mutational signature of CX5461, a photosensitiser, when combined with UVA light, showing increased SNV burden only in co-exposed cells.
bioRxiv · Apr 14, 2026 · PreprintCancer Biology